CEBA: A new heterobifunctional reagent for plasmid DNA functionalization by click chemistry

DNA functionalization by dynamic chemistry

Dynamic combinatorial chemistry (DCC) is an attractive method to efficiently generate libraries of molecules from simpler building blocks by reversible reactions under thermodynamic control. Here we focus on the chemical modification of DNA oligonucleotides with acyclic diol linkers and demonstrate their potential for the deoxyribonucleic acid functionalization and generation of libraries of re...

Functionalization of polymer microspheres using click chemistry.

We describe a new method to covalently link a wide variety of molecules to the surface of colloidal polymer microspheres using the Cu(I)-catalyzed azide-alkyne reaction, most commonly known under the class of reactions identified by the term click chemistry. The method is generic and readily applied to a spectrum of colloidal particle systems allowing surfaces to be tailored with virtually any ...

Surface Functionalization of Exosomes Using Click Chemistry

A method for conjugation of ligands to the surface of exosomes was developed using click chemistry. Copper-catalyzed azide alkyne cycloaddition (click chemistry) is ideal for biocojugation of small molecules and macromolecules to the surface of exosomes, due to fast reaction times, high specificity, and compatibility in aqueous buffers. Exosomes cross-linked with alkyne groups using carbodiimid...

Functionalization of polymers with phosphorescent iridium complexes via click chemistry.

We report a simple yet highly efficient route to prepare polymers with a variety of pendant iridium complexes as potential materials in organic light-emitting diodes by employing click chemistry.

Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag**